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Model of TP53 stabilization and activation by the HPV16 E7 oncoprotein. HPV16 E7 expression triggers DINO expression at least in part through a KDM6A-mediated pathway. This causes TP53 activation, which results in further TP53-mediated DINO transcription. Despite the induction of the MDM2 ubiquitin ligase inhibitor p14ARF as a consequence of HPV16-mediated RB1 degradation, p14ARF has no or minimal effect on E7-mediated TP53 stabilization in keratinocytes. See the text for details.
