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. 2020 Jun 16;94(13):e02025-19. doi: 10.1128/JVI.02025-19

FIG 4.

FIG 4

Viral replicative capacity (VRC) of T280X/R286K B clade and V280X/K286R C clade mutant viruses. (A) Relative VRC of the consensus sequence normalized to that of the B clade wild type (WT) (NL4-3). (B) Relative VRC of B clade viruses normalized to that of the B clade wild type (NL4-3). (C) Relative VRC of C clade viruses normalized to that of the C clade wild type [SK-254(M)]. (D) Relative VRC of IC viruses normalized to that of the IC wild type. All bars are shown as means with standard deviations. Patterned bars represent the R286K/K286R mutant. Clades are indicated according to the color legend [blue, NL4-3; yellow, SK-254(M); green, Indian C clade consensus (IC)]. One-way ANOVA multiple comparison and Dunnett’s correction were used for calculating P values. Asterisks indicate P values for comparison of the results with the mutant virus to those with the wild type (ns, not significant [P ≥ 0.05]; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001).