Figure 4.

Deposition of CENPA at regulatory regions across the genome in the VCaP prostate cancer cell line. A, heat map across 4-kb windows of CENPA ChIP versus input signals centered at the CENPA peaks. B, UCSC Genome Browser illustration of CENPA binding to transcriptional start site (TSS) of the CDC25C gene on chromosome 5. C, 569 CENPA peaks were subjected to Gene Ontology assessment. Representative concepts are rank ordered by their FDR. D, CENPA peaks were annotated against 16 genomic regions relative to known genes. CDS, coding sequence; CGI, CpG Island. Peak abundance (black bars) was compared with abundance from random selection (gray bars) within each genomic region.