Table 2.

The second passage of brain homogenates of animals infected with SMA-isolated Hyper PrP^Sc into healthy Syrian hamsters

Reinoculation sample (hamster)	Incubation period ± S.E.	N/N0
	days
1% 263K brain homogenate (control)	71 ± 0.5	4/4
Treated with 1% SMA(1:1)ma-PrPSc	87 ± 3a	10/10a
Treated with 1% SMA(2:1)-PrPSc	74 ± 3	6/6
Treated with 1% SMA-SH-PrPSc	97 ± 2a	6/6a
Treated with 1% SMA(3:1)-PrPSc	115 ± 0.5a	6/6a

^a Significant difference (p value < 0.001) between the incubation periods of SMA-treated samples and the control. The largest differences were in SMA-SH-PrP^Sc and SMA(3:1)-PrP^Sc, as seen in the first passage (Table 1).