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. 2020 May 11;295(25):8613–8627. doi: 10.1074/jbc.RA119.010266

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© 2020 Chen et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 2. — GluN3A contributes to the program of NMDAR-inducible transcription. A, Volcano plot showing genes significantly different at an FDR-adjusted p < 0.05 (red dots) comparing Ctrl TTX w/d with Grin3a KD TTX w/d. B, Venn diagram showing genes significantly induced by TTX w/d in Ctrl neurons (red) compared with genes reduced in Grin3a KD versus Ctrl after TTX w/d (blue). C, Venn diagram showing genes significantly repressed by TTX w/d in Ctrl neurons (blue) compared with genes with higher expression in Grin3a KD compared with Ctrl after TTX w/d (red). D, Heat map showing the relative expression of the 113 genes is higher after TTX w/d in Grin3a KD compared with Ctrl that are either unchanged or induced by TTX w/d in Ctrl. n = 3 biological replicates per sample. Heat map shows the z-score for FPKM.