Table 3.
Upstream regulators enriched in 569 E2-regulated uterine genes identified in Fig. 4D
| Upstream regulator | Activation z-score, 2 h | Activation z-score, 6 h | p value of overlap |
|---|---|---|---|
| TGFB1a | 5.32 | 5.27 | 1.77E−11 |
| β-Estradiol | 4.63 | 4.54 | 1.16E−12 |
| LIF | 3.12 | 2.29 | 3.01E−05 |
| Cytokineb | 3.06 | 3.06 | 1.3E−06 |
| PGR | 2.92 | 2.92 | 5.14E−07 |
| Ige | 2.62 | 2.07 | 2.86E−05 |
| GDF2 | 2.61 | 2.61 | 2.44E−06 |
| ERK1/2c | 2.50 | 2.62 | 2.84E−05 |
| IGF1 | 2.35 | 4.41 | 3.49E−06 |
| α-Catenin | −2.51 | −2.11 | 1.22E−10 |
a Includes TGFB1, TGFB3, and SMAD3.
b Includes CSF1, CSF2, EDN1, IFNG, IL1, IL17A, IL1A, IL1B, IL2, Il3, IL4, IL6, OSM, TNF, and TNFSF11.
c Includes EGF, ERBB2, MAPK3, MAPK8, MAPK9, and p38 MAPK.