. Author manuscript; available in PMC: 2020 Jun 22.

Published in final edited form as: Semin Liver Dis. 2015 Jan 29;35(1):36–42. doi: 10.1055/s-0034-1397347

Table 2.

microRNAs in liver diseases

MicroRNA	Target genes
miR-155	TNFα (positive regulation), SOCS-1, SHIP-1
miR-132	Neuroimmune microRNA
miR-122	Lipid metabolism: HMCCoA, ApoE, MTTP, PCC1a
	Fibrosis: P4HA1
	Hepatocellular cancer: Igf1R, ADAM10, cyclin G1, KLF6
miR-21	Fibrosis
miR-26a	Hepatocellular cancer

Abbreviations: ADAM10, a disintegrin and metalloproteinase domain-containing protein 10; ApoE, apolipoprotein E; HMGCoA, 3-hydroxy-3-methylglutaryl-coenzymeA; Igf1R, insulin-like growth factor 1 receptor; KLF6, Kruppel-like factor 6; PGC1a, PPAR-gamma coactivator 1-alpha; SHIP-1, Src Homology-2 domain containing inositol 5-phosphate-1; SOCS, suppressor of cytokine signaling; TNFα, tumor necrosis factor alpha.