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. 2020 Mar 2;34(6):e23252. doi: 10.1002/jcla.23252

Figure 4.

Figure 4

CircRNA_103762 enhanced multidrug resistance by inhibited CHOP expression in NSCLC cells. The CHOP expression was detected by RT‐PCR (A) and Western blot (B) in H358 and H358/si‐circRNA_103762. The CHOP expression was detected by RT‐PCR (C) and Western blot (D) in H358 and H358/CDDP. The CHOP expression was detected by RT‐PCR (E) and Western blot (F) in H358, H358/si‐circRNA_103762 and H358/siRNA/si‐CHOP. The CHOP expression was detected by RT‐PCR (G) and Western blot (H) in H358, H358/CDDP/si‐circRNA_103762 and H358/CDDP/si‐circRNA_103762/si‐CHOP. I, The IC50 of different drugs on H358, H358/si‐circRNA_103762 and H358/si‐circRNA_103762/si‐CHOP. J, The IC50 of different drugs on H358/CDDP, H358/CDDP/si‐circRNA_103762 and H358/CDDP/si‐circRNA_103762/si‐CHOP. The data shown represent the mean ± SD (n = 3). *P < .05, **P < .01, ***P < .001. All siRNA is si‐circRNA_103762