Table 3.

Genotype frequencies of BTLA tagging SNPs and ESCC risk

Genotype	ESCC cases (n = 721)		Controls (n = 1208)		Crude OR (95% CI)	P	Adjusted OR (95% CI)a	P
	n	%	N	%
rs2171513 G > A
GG	463	64.85	774	64.45	1.00		1.00
GA	227	31.79	380	31.64	1.00 (0.82‐1.22)	.989	0.99 (0.80‐1.22)	.888
AA	24	3.36	47	3.91	0.85 (0.52‐1.42)	.539	0.80 (0.47‐1.37)	.424
GA + AA	251	35.15	427	35.55	0.98 (0.81‐1.19)	.860	0.96 (0.79‐1.19)	.730
GG + GA	690	96.64	1154	96.09	0.85 (0.52‐1.41)	.537	0.81 (0.47‐1.37)	.430
A allele	275	19.26	474	19.73
rs3112270 A > G
AA	387	54.43	614	51.12	1.00		1.00
AG	259	36.43	500	41.64	0.82 (0.68‐1.00)	.051	0.84 (0.68‐1.04)	.109
GG	65	9.14	87	7.24	1.19 (0.84‐1.68)	.335	1.27 (0.88‐1.83)	.204
AG + GG	324	45.57	587	48.88	0.88 (0.73‐1.06)	.162	0.91 (0.74‐1.10)	.324
AA + AG	646	90.86	1114	92.76	1.29 (0.92‐1.80)	.139	1.36 (0.96‐1.95)	.087
G allele	389	27.36	674	28.06
rs1982809 G > A
GG	408	57.22	657	54.70	1.00		1.00
GA	252	35.35	464	38.64	0.88 (0.72‐1.07)	.182	0.93 (0.75‐1.15)	.488
AA	53	7.43	80	6.66	1.07 (0.74‐1.54)	.731	1.30 (0.88‐1.91)	.189
GA + AA	305	42.78	544	45.30	0.90 (0.75‐1.09)	.284	0.98 (0.80‐1.20)	.841
GG + GA	660	92.57	1121	93.34	1.13 (0.79‐1.61)	.521	1.34 (0.92‐1.95)	.134
A allele	358	25.11	624	25.98
rs16859629 T > C
TT	622	87.61	997	84.06	1.00		1.00
TC	85	11.97	181	15.27	0.75 (0.57‐0.99)	.044	0.82 (0.61‐1.10)	.191
CC	3	0.42	8	0.67	0.60 (0.16‐2.28)	.454	0.82 (0.21‐3.23)	.777
CT + CC	88	12.39	189	15.94	0.75 (0.57‐0.98)	.035	0.82 (0.62‐1.10)	.184
TT + CT	707	99.58	1178	99.33	0.63 (0.17‐2.36)	.489	0.85 (0.22‐3.33)	.809
C allele	91	6.31	197	8.15

Bold values are statistically significant (P < .05).

Abbreviations: CI, confidence interval; OR, odds ratio.

^aAdjusted for age, sex, smoking status, and alcohol use in a logistic regression model.