Table 7.

Stratified analyses between BTLA rs16859629 T > C polymorphism and ESCC risk by sex, age, smoking status, and alcohol consumption

Variable	BTLA rs16859629 T > C (case/control)a			Adjusted OR (95% CI)b; P
	TT	TC	CC	TT	TC vs TT	CC vs TT	TC/CC vs TT	CC vs (TT/TC)
Sex
Male	469/739	68/138	3/5	1.00	0.87 (0.63‐1.22); P: .433	1.73 (0.39‐7.65); P: .469	0.90 (0.65‐1.25); P: .519	1.77 (0.40‐7.82); P: .451
Female	153/258	17/43	0/3	1.00	0.68 (0.37‐1.25); P: .213	‐	0.63 (0.34‐1.14); P: .125	‐
Age
<63	295/481	37/85	0/3	1.00	0.79 (0.50‐1.24); P: .305	‐	0.75 (0.48‐1.18); P: .215	‐
≥63	327/516	48/96	3/5	1.00	0.85 (0.57‐1.25); P: .398	1.41 (0.32‐6.21); P: .649	0.87 (0.59‐1.27); P: .466	1.45 (0.33‐6.38); P: .623
Smoking status
Never	292/716	42/143	3/7	1.00	0.74 (0.51‐1.08); P: .116	0.97 (0.24‐3.92); P: .968	0.75 (0.52‐1.08); P: .126	1.02 (0.25‐4.10); P: .981
Ever	330/281	43/38	0/1	1.00	0.98 (0.61‐1.58); P: .931	‐	0.95 (0.59‐1.54); P: .847	‐
Alcohol consumption
Never	436/863	58/157	3/7	1.00	0.78 (0.56‐1.09); P: .145	0.99 (0.25‐3.99); P: .988	0.79 (0.57‐1.09); P: .154	1.03 (0.26‐4.14); P: .971
Ever	186/134	27/24	0/1	1.00	1.00 (0.52‐1.90); P: .993	‐	0.95 (0.50‐1.80); P: .879	‐
BMI (kg/m2)
<24	455/534	61/96	2/5	1.00	0.82 (0.57‐1.17); P: .275	0.75 (0.14‐3.97); P: .734	0.82 (0.57‐1.16); P: .259	0.77 (0.15‐4.09); P: .761
≥24	167/463	24/85	1/3	1.00	0.84 (0.51‐1.39); P: .508	1.07 (0.10‐11.24); P: .958	0.85 (0.52‐1.39); P: .522	1.09 (0.10‐11.53); P: .941

Abbreviations: BMI, body mass index; CI, confidence interval; OR, odds ratio.

^aThe genotyping was successful in 710 (98.47%) ESCC cases and 1186 (98.18%) controls for BTLA rs16859629 T > C.

^bAdjusted for age, sex, smoking status, and alcohol consumption (besides stratified factors accordingly) in a logistic regression model.