Figure 5.
Novel object recognition memory assessed during abstinence from METH or saccharin self-administration. Schematic of the novel object recognition task with red object indicating the novel target (A). Exploration ratios during the test phase for naïve rats (B) or rats with a history of METH (C) or saccharin (D) self-administration. Bars represent exploration ratio averaged across the 3-min test phase with data points representing individual animal data. Exploration ratios were calculated as timenovel / (timenovel + timefamiliar). Dotted red line indicates chance performance (0.5). We found no significant sex difference, so data are presented collapsed across sex. * p < 0.05 vs. min 1, # p < 0.001 vs. min 1 within adolescent-onset.