Figure 3. Unweighted Unifrac distance based on thePrincipal coordinate analysis (PCoA) (A), UPGMA (unweighted pair group method with arithmetic mean) clustering graph (B) and Anosim analysis (C).

R-value is between (−1, 1), and R-value is greater than 0, indicating significant difference between groups, or indicating that the intra-group difference was greater than the inter-group difference, and P < 0.05 indicated statistical significance.