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. 2020 Jun 21;8(1):e000622. doi: 10.1136/jitc-2020-000622

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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DUOX1 controls macrophage differentiation, activation and secretion in vitro. (A) Macrophage precursors from WT or Duox1^−/− bone marrow were cultured for 6 days in the presence of recombinant GM-CSF. (B) Supernatants from cultured bone marrow–derived macrophages (BMDMs) were analyzed for cytokine secretion. Data were obtained from two independent experiments and are represented as the mean±SEM. n=6–8, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 (Student’s t-test). (C) The phenotype of cultured BMDMs was analyzed by flow cytometry. Data were obtained from two independent experiments and are represented as the mean±SEM. n=4, ****p<0.0001 (two-way ANOVA).