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. 2020 Jun 21;8(1):e000622. doi: 10.1136/jitc-2020-000622

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Duox1^−/− proinflammatory macrophages induce IFNγ production by lymphoid cells in irradiated tumors. Three days after bone marrow–derived macrophage (BMDM) injection, the tumors were harvested, and lymphoid immune cells were analyzed by flow cytometry. (A) The numbers of tumor-infiltrating CD4⁺ T cells, CD8⁺ T cells, natural killers (NKs) and Tregs are presented for each treated group. (B) The percentages of IFNγ⁺ tumor-infiltrating CD4⁺ T cells, CD8⁺ T cells and NKs are shown. (C) Representative histograms of IFNγ⁺ tumor-infiltrating CD4⁺ T cells, CD8⁺ T cells and NKs are shown. Data were obtained from two independent experiments and are represented as the mean±SEM. n=7–8, *p<0.05, **p<0.01 (two-way ANOVA).