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. 2020 Jun 21;8(1):e000622. doi: 10.1136/jitc-2020-000622

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Duox1^−/− proinflammatory macrophages induce IFNγ production by myeloid cells in irradiated tumors. Three days after bone marrow–derived macrophage (BMDM) injection, the tumor-infiltrating myeloid cells were analyzed by flow cytometry. (A) The numbers of tumor-infiltrating macrophages, Ly6^high Mo and cDC1 are shown. (B) The percentages of IFNγ⁺ tumor-infiltrating macrophages, Ly6^high Mo and cDC1 are presented for each treatment group. (C) Representative histograms of IFNγ⁺ tumor-infiltrating macrophages, Ly6^high Mo and cDC1 are shown. Data were obtained from two independent experiments and are represented as the mean±SEM. n=7–8, *p<0.05, **p<0.01 (two-way ANOVA).