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. 2020 Jun 4;57(2):500–508. doi: 10.3892/ijo.2020.5077

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of MH, EDA and Bru on the levels of oxidative stress indicators, neuronal viability, cytotoxicity and caspase-3 activity. (A-E) The levels of MDA, GSH, GSH-PX, CAT and SOD in rat ischemic hemispheres tissues were determined by colorimetric methods; n=10 mice per group. (F) The viability of neurons from the CA1 region of hippocampi was determined by the MTT assay. (G and H) Cytochrome c and caspase-3 in the mitochondrial fractions from each group was detected by ELISA. ^***P<0.001 vs. sham. ^#P<0.1, ^##P<0.01 and ^###P<0.001 vs. MCAO. ^{^}P<0.1, ^{^^}P<0.01 and ^{^^^}P<0.001 vs. MCAO + MH + EDA. MCAO, middle cerebral artery occlusion; MH, mild hypothermia; EDA, edaravone; Bru, brusatol; MDA, malondialdehyde; GSH, glutathione; GSH-PX, glutathione peroxidase; CAT, catalase; SOD, superoxide dismutase.