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. 2020 Jun 4;57(2):500–508. doi: 10.3892/ijo.2020.5077

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of MH, EDA and Bru on the activation of the Nrf2/HO-1 pathway. (A-E) Western blot analyses of expressions of cNrf2, HO-1, NQO1, β-actin, nNrf2 and histone H3 in rat ischemic hemisphere tissues; n=10 mice per group. ^**P<0.01 and ^***P<0.001 vs. sham. ^##P<0.001 and ^###P<0.001 vs. MCAO. ^{^}P<0.1, ^{^^}P<0.01 and ^{^^^}P<0.001 vs. MCAO + MH + EDA. MCAO, middle cerebral artery occlusion; MH, mild hypothermia; EDA, edaravone; Bru, brusatol; Nrf2, nuclear factor erythroid 2-related factor 2; cNrf2, cytoplasmic Nrf2; nNrf2, nuclear Nrf2; HO-1, heme oxygenase-1; NQO1, NAD(P)H quinone oxidoreductase.