Figure 8.

Protein levels of FAM83A and integrins α1, α3, α5, β4 and β5 in human cervical cancer specimens. (A) Representative images of the staining of FAM83A and integrins α1, α3, α5, β4 and β5 in tissues from patients with cervical cancer in the high and low FAM83A expression groups. 'High' and 'low' in each image indicate each protein level separately. (B) Relative protein expressions of FAM83A and integrins in cervical cancer tissues from patients in the low and high FAM83A expression groups determined by immunohistochemistry analysis (n=10 patients per group). (C) Schematic diagram demonstrating that upregulation of FAM83A inhibits the PI3K/AKT and TNF signaling, focal adhesion and ECM-receptor interaction oncogenic pathways, followed by inhibition of certain integrins to attenuate cervical cancer progression. FAM83A, family with sequence similarity 83 member A; TNF, tumor necrosis factor; ECM, extracellular matrix.