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. 2020 May 19;57(2):456–465. doi: 10.3892/ijo.2020.5068

Figure 6.

Figure 6

LPS-induced PD-L1 upregulation is inhibited by the MEK inhibitor but not PI3K inhibitor. A549 cells were treated with LPS and the MEK inhibitor PD98059 or the PI3K inhibitor LY294002 at their indicated concentration prior to western blotting. (A) Representative image of the blots of PD-L1 and corresponding semi-quantitative densitometric analysis following treatment with LPS and/or PD98059. (B) Representative image of the blots of PD-L1 and cor-responding semi-quantitative densitometric analysis following treatment with LPS and/or LY294002. (C) Measurement of PD-L1 mRNA expression following treatment with (C) LPS and/or PD98059. (D) Measurement of PD-L1 mRNA expression following treatment with LPS and/or LY294002. Data are presented as the means ± SD. *P<0.05 and ***P<0.001 vs. con. &P<0.05 and #P<0.0.001 vs. LPS. LPS, lipopolysaccharides; Con, control; PD-L1, programmed-death ligand 1.