Table II.
Univariate and multivariate analysis of the clinicopathologic factors in patients with NSCLC with respect to overall survival.
| Parameters | Cases | Univariate analysis
|
Multivariate analysis
|
||
|---|---|---|---|---|---|
| Survive time | P-value | HR (95% CI) | P-value | ||
| Gender | 0.609 | ||||
| Male | 48 | 36.06±3.29 | |||
| Female | 12 | 35.42±5.16 | |||
| Age (years) | 0.845 | ||||
| >60 | 21 | 39.1±4.75 | |||
| ≤60 | 39 | 37.92±3.54 | |||
| Histology type | 0.293 | ||||
| SCC | 27 | 41.63±4.48 | |||
| ADC | 33 | 35.64±3.57 | |||
| Grade | 0.177 | ||||
| High-middle | 42 | 40.83±3.36 | |||
| Low | 18 | 32.5±5.03 | |||
| Lymphatic invasion | 0.013 | ||||
| Negative | 30 | 31.47±3.73 | 0.557 (0.246-1.258) | 0.159 | |
| Positive | 30 | 45.2±3.88 | |||
| Tumor size (cm) | 0.355 | ||||
| ≤3 | 20 | 42.05±4.79 | |||
| >3 | 40 | 36.48±3.48 | |||
| TNM stage | 0.009 | ||||
| I +II | 39 | 43.67±3.33 | 1.24 (0.538-2.86) | 0.614 | |
| III | 21 | 28.43±4.47 | |||
| PD-L1 | 0.023 | ||||
| Positive | 37 | 33.32±3.36 | 0.663 (0.31-1.422) | 0.291 | |
| Negative | 23 | 46.39±4.57 | |||
| TLR4 | 0.014 | ||||
| Positive | 31 | 31.71±3.85 | 0.591 (0.298-1.17) | 0.131 | |
| Negative | 29 | 45.41±3.75 | |||
Overall survival time was presented as mean ± SEM and was determined by the Kaplan-Meier method with log-rank test. Multivariable analysis of the independent factors was performed using the Cox proportional hazard model. PD-L1, programmed cell death ligand 1; TLR4, toll-like receptor 4; SCC, squamous cell carcinoma; ADC, adenocarcinoma; HR, hazards ratio; CI, confidence interval.