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. 2020 May 14;57(2):478–487. doi: 10.3892/ijo.2020.5066

Figure 2.

Figure 2

Cytobiological changes of A431 and SCL-1 cells transfected with circ-0070934 siRNA or overexpression plasmids. (A) Knockdown of circ-0070934 suppressed cell proliferation, whereas circ-0070934 overexpression exerted the opposite effect. Cell Counting Kit-8 assays were performed to determine cell proliferation (left). Typical images of proliferating cells in EdU assays are presented (middle). The proliferating cells were quantified (right). (B) Transwell assays demonstrated that the knockdown of circ-0070934 inhibited cell invasion, whereas circ-0070934 overexpression had the opposite effect. (C) Flow cytometry results indicated that knockdown of circ-0070934 increased apoptosis compared with that in the control group, whereas circ-0070934 overexpression has an adverse effect. All experiments were conducted in triplicate. Data are reported as the mean ± SD. *P<0.05, **P<0.01, ***P<0.001 vs. siNC + vector. Circ, circular RNA; si, small interfering RNA; OE, overexpression vector.