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. 2020 May 14;57(2):478–487. doi: 10.3892/ijo.2020.5066

Figure 4.

Figure 4

Circ-0070934 regulates HOXB7 by sequestering miR-1236-3p. (A) The binding sequence of WT HOXB7 and miR-1236-3p was predicted, and the MUT HOXB7 sequence was constructed. (B) Dual-luciferase reporter gene experiments demonstrated that HOXB7 interacted with miR-1236-3p. (C) The expression levels of HOXB7 were upregulated in cutaneous squamous cell carcinoma cell lines compared with those in HaCaT cells. (D) Western blotting analysis revealed that compared with those in HaCaT cells, the expression levels of the HOXB7 protein were significantly elevated in A431 and SCL-1 cells. All experiments were conducted in triplicate. Data are reported as the mean ± SD. *P<0.05, **P<0.01 vs. HaCaT or as indicated. Circ, circular RNA; HOXB7, homeobox B7; miR, microRNA; WT, wild-type; MUT, mutant.