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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Cancer Res. 2020 Jan 16;80(7):1578–1589. doi: 10.1158/0008-5472.CAN-19-2669

Figure 7: Evolutionary velocity before and during therapy.

Figure 7:

Columns show evolutionary velocity of simulations identical to figure 4 for no treatment, Lupron, and Lupron + Abiraterone. A-C: note that no treatment is characterized by mostly slow velocities (blue) while adding treatments increases velocities, except when approaching evolutionary stable points (circles). D - L: rows show subpopulation relative velocity for T+ (D, E, F), TP (G, H, I), and T− (J, K, L). Adaptive therapy relies on the suppression of the resistant population (T−) by the sensitive populations (T+, TP) during treatment holidays (first column). This is only possible in certain a subset of the state space (blue; where T− velocity < 0). Velocities calculated by eqn. 1: see Supporting Information.