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. 2020 Jun 15;7(3):ENEURO.0009-20.2020. doi: 10.1523/ENEURO.0009-20.2020

Figure 9.

Figure 9.

Representative micrographs illustrating, on the coronal plane, the negligible expression of PK-resistant α-syn immunoreactivity at seven, nine, and 12 months postinjection in the vertical limb of the DBB (vDBB; A, inset shown in A′), and the anterior and posterior piriform cortices (aPC and pPC; B, C, respectively, insets shown in B′, C′). Spreading of α-syn aggregates. A strong PK-resistant α-syn immunoreactivity was also found at 12 months postinjection in the vDBB (D, inset shown in D′, arrow) and the anterior and posterior piriform cortices (aPC and pPC, E, F, insets shown in E′, F′; arrows and arrowheads indicate LB-like and LN-like inclusions, respectively). Scale bar: 100 μm (in A, D, for A–C, D–F) and 50 μm (D for D–F). Cresyl violet staining of the entorhinal cortex (ENT CTX), hippocampus (HPC), and piriform cortices (PC) of control (G, H, I, respectively) and α-syn-injected animals (J, K, L, respectively). Scale bar: 100 μm (in G for G–L).