Figure 3.

A, Skin levels of t-AUCB, quantified by liquid chromatography coupled to tandem mass spectrometry, 2 (n=5) and 24 hours (n=6) after topical application of the t-AUCB-containing gel (20 μL at 400 mg/L) on the dorsal skin of db/db mice. B, Thermal hyperemia measured by laser Doppler imaging before (n=19), 2 (n=13) and 24 hours (n=6) after the topical application of the t-AUCB-containing gel on the dorsal skin of db/db mice. *P<0.05 vs. before topical application. A.P.U.: arbitrary perfusion unit.