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. 2020 Jun 17;3(3):198–210. doi: 10.1089/crispr.2019.0075

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© Jivan Khlghatyan and Jean-Martin Beaulieu 2020; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 5. — GSK3β of mPFC D2 neurons contributes to cognitive and social behaviors. (A) Novel object recognition (NOR) test for Ctrl and Gsk3sKO in mPFC D2 mice in session 1. (B) Total time spent with both objects (session 1 Ctrl: 49 ± 3.9 s n = 19; Gsk3sKO in mPFC D2: 50.9 ± 3.8 s, n = 19). (C) Difference in time spent with object 2 versus object 1 (session 1 Ctrl: −0.7 ± 0.8 s n = 19; Gsk3sKO in mPFC D2: −2 ± 0.7 s n = 19). (D) NOR test for Ctrl and Gsk3sKO in mPFC D2 mice in session 2 (*p < 0.05; ***p < 0.001; paired t-test). (E) Total time spent with both objects (session 2 Ctrl: 16.1 ± 1.2 s n = 19; Gsk3sKO in mPFC D2: 19.1 ± 1.6 s n = 19). (F) Difference in time spent with object 3 versus object 1 (session 2 Ctrl: 4.8 ± 0.7 s n = 19; Gsk3sKO in mPFC D2: 2.1 ± 0.9 s n = 19; *p < 0.05; Student's t-test). Preference for social novelty for Ctrl and Gsk3sKO in mPFC D2 mice. (G) Session 1 (time difference object–mouse: Ctrl: −52 ± 6.8 s n = 19; Gsk3sKO in mPFC D2: −48.4 ± 6.1 s n = 19). (H) Session 2 (time difference mouse 2–mouse 1: Ctrl: 42.5 ± 11.5 s n = 19; Gsk3sKO in mPFC D2: 31.3 ± 8.3 s n = 19; **p < 0.01; ***p < 0.001; paired t-test). (I) Free social interaction test for Ctrl and Gsk3sKO in mPFC D2 mice. Time in interaction (Ctrl: 33.3 ± 3.1 s n = 18; Gsk3sKO in mPFC D2: 25.1 ± 2.2 s n = 18; *p < 0.05; Student's t-test). Error bars show SEM.