FIG. 1.

Genomic organization of Asgard-specific derivatives of CRISPR-Cas systems and Cas1-containing modules. For each locus, the metagenome-assembled genome contig identifier and the respective nucleotide coordinates are indicated. The genes of a representative locus are shown by arrows. The arrows indicate the transcription direction of the respective gene. Genes are shown roughly to scale. Homologous genes are colored according to the respective insets. Genes are shown to the same scale in (A)–(C). (A) ARAMP: degraded Class1 CRISPR-Cas systems. (B) aCas1_2-containing modules. (C) aCas1_3-TnpB modules. (D) Domain architectures of aCas1 families. Domains are shown as rectangles drawn roughly to scale. The Cas1 homologous domains are highlighted by red borders.