. 2020 Jun 9;37(13):1491–1503. doi: 10.1089/neu.2019.6866

Table 1.

SNPs Investigated for Inclusion in PRS

Gene	SNP	Chrom	Pos	Ref allele	Alt allele	MAF	Consequence	CADD
ACE	rs4329	17	61563458	A	G^a	0.45	Intronic	5.19
ACE	rs4331	17	61564052	A	G^a	0.45	Synonymous	5.337
ACE	rs4343	17	61566031	G^a	A	0.48	Synonymous	5.011
ACE	rs4362	17	61573761	T	C^a	0.49	Synonymous	6.02
ACE	rs4611524	17	61591652	T^a	C	0.42	Intronic	12.12
ADORA1	rs17042888	2	113862173	G	A^a	0.10	Upstream	0.141
ADORA1	rs13382561	2	113863536	A	G^a	0.38	Upstream	7.067
ADORA1	rs11677140	2	113865808	A	C^a	0.29	Upstream	0.041
ADORA1	rs1688072	2	113869347	A	G^a	0.16	Intronic	3.568
BDNF	rs988712	11	27563382	G	T^a	0.21	Intronic	14.38
BDNF	rs7481311	11	27583129	T^a	C	0.25	Intronic	3.02
BDNF	rs10835201	11	27618265	A	G^a	0.26	Intronic	12.33
BDNF	rs10734394	11	27628412	G^a	A	0.27	Intronic	12.39
BDNF	rs6416056	11	27646745	G^a	A	0.30	Intronic	0.479
BDNF	rs4074134	11	27647285	C	T^a	0.21	Intronic	0.494
BDNF	rs925946	11	27667202	T^a	G	0.28	Intronic	3.007
BDNF	rs1519480	11	27675712	C^a	T	0.42	Downstream	2.23
BDNF	rs6265	11	27679916	C	T^a	0.17	Non-synonymous	2.099
BDNF	rs10767664	11	27725986	T^a	A	0.19	Upstream	4.935
BDNF	rs2030323	11	27728539	A^a	C	0.19	Intronic	1.449
BDNF	rs7934165	11	27731983	G	A^a	0.47	Intronic	2.987
IL1RN	rs17042888	2	113862173	G	A^a	0.10	Upstream	0.141
IL1RN	rs13382561	2	113863536	A	G^a	0.38	Upstream	7.067
IL1RN	rs11677140	2	113865808	A	C^a	0.29	Upstream	0.041
IL1RN	rs1688072	2	113869347	A	G^a	0.16	Intronic	3.568
IL1RN	rs315931	2	113869843	C^a	A	0.34	Intronic	11.81
IL1RN	rs315919	2	113876213	T^a	G	0.43	Intronic	0.089
IL1RN	rs3213448	2	113879297	G	A^a	0.16	Intronic	4.257
IL1RN	rs423904	2	113887262	C	T^a	0.24	Intronic	3.562
IL1RN	rs315952	2	113890304	T	C^a	0.31	Synonymous	0.388
NT5E	rs6942065	6	86168265	G	A^a	0.16	Intronic	18.54
NT5E	rs10944128	6	86180732	A	C^a	0.50	Intronic	21.4
NT5E	rs2229523	6	86199233	A^a	G	0.29	Non-synonymous	19.93
NT5E	rs2229524	6	86199243	T	C^a	0.11	Non-synonymous	8.24

^{^a}

Minor allele.

ACE, angiotensin converting enzyme; ADORA1, adenosine A1 receptor subtype gene; Alt, alternative; BDNF, brain-derived neurotrophic factor; CADD, Combined Annotation Dependent Depletion score;⁵⁷ Chrom, chromosome; IL1RN, interleukin-1 receptor antagonist; MAF, minor allele frequency; NT5E, 5’-ectonucleotidase; Pos, position; SNP, single nucleotide polymorphism; downstream, the DNA variant allele occurs outside the coding region of the gene, after the gene; these regions may affect gene regulation; intronic: the DNA variant allele occurs within a gene, but between the regions coding for protein; these regions may affect gene regulation; non-synonymous, the DNA variant allele alters the sequence of the coding region of a gene and alters the amino acid sequence; the protein structure will be altered; synonymous, the DNA variant allele alters the sequence of the coding region of a gene but the amino acid sequence remains the same; although the protein is not changed, variants in these regions could affect gene regulation; upstream: the DNA variant allele occurs outside the coding region of the gene, before the gene; these regions may affect gene regulation.