Table 4.
SNPs Identified for Inclusion in PRS Based on Results of General Linear Regression Models in the TBI Group
| Gene | SNPs | EF β | EF p | Adj R2 | BA β | BA p | Adj R2 |
|---|---|---|---|---|---|---|---|
| ACE | rs4343 | -2.4 | 0.266 | 0.282 | 0.06 | 0.978 | 0.335 |
| ACE | rs4362 | 2.6 | 0.187 | 0.288 | 0.13 | 0.946 | 0.335 |
| ACE | rs4329 | 3.9 | 0.067 | 0.306 | 0.8 | 0.702 | 0.337 |
| ACE | rs4611524 | 1.3 | 0.48 | 0.274 | 1.67 | 0.369 | 0.344 |
| ADORA1 | rs10920576 | 0.2 | 0.951 | 0.268 | 1.48 | 0.563 | 0.339 |
| ADORA1 | rs11590405 | 1.3 | 0.563 | 0.272 | -0.74 | 0.732 | 0.337 |
| ADORA1 | rs17465037 | -0.3 | 0.899 | 0.268 | -0.18 | 0.930 | 0.335 |
| ADORA1 | rs6686206 | 2.3 | 0.39 | 0.277 | 2.18 | 0.407 | 0.343 |
| ADORA1 | rs6701725 | -0.1 | 0.969 | 0.268 | -1.42 | 0.492 | 0.340 |
| BDNF | rs7934165 | -3.6 | 0.057 | 0.309 | -2.9 | 0.127 | 0.360 |
| BDNF | rs10734394 | 1.2 | 0.544 | 0.272 | -0.15 | 0.937 | 0.335 |
| BDNF | rs1519480 | 0.5 | 0.799 | 0.269 | -0.13 | 0.949 | 0.335 |
| BDNF | rs925946 | 0.8 | 0.691 | 0.270 | 0.56 | 0.779 | 0.336 |
| BDNF | rs10835201 | 0.2 | 0.93 | 0.268 | 1.05 | 0.61 | 0.338 |
| BDNF | rs7481311 | 0.2 | 0.929 | 0.268 | 2.16 | 0.312 | 0.346 |
| BDNF | rs988712 | 2.6 | 0.292 | 0.281 | 2.17 | 0.363 | 0.344 |
| BDNF | rs6416056 | 4.5 | 0.053 | 0.311 | 2.48 | 0.275 | 0.348 |
| BDNF | rs4074134 | 4.1 | 0.094 | 0.300 | 2.65 | 0.264 | 0.349 |
| BDNF | rs2030323 | 4.1 | 0.103 | 0.298 | 3.27 | 0.176 | 0.355 |
| IL1RN | rs315931 | -3.2 | 0.09 | 0.301 | -3.12 | 0.097 | 0.364 |
| IL1RN | rs11677140 | -1.7 | 0.402 | 0.276 | -2 | 0.331 | 0.345 |
| IL1RN | rs423904 | -1.1 | 0.66 | 0.270 | -1.25 | 0.606 | 0.338 |
| IL1RN | rs315952 | -0.3 | 0.907 | 0.268 | -0.92 | 0.676 | 0.337 |
| IL1RN | rs315919 | -3.3 | 0.078 | 0.304 | -0.82 | 0.663 | 0.337 |
| IL1RN | rs1688072 | 0.9 | 0.702 | 0.270 | -0.57 | 0.814 | 0.336 |
| IL1RN | rs3213448 | -3.9 | 0.155 | 0.291 | 0.06 | 0.984 | 0.335 |
| IL1RN | rs13382561 | 2.1 | 0.249 | 0.283 | 0.33 | 0.858 | 0.336 |
| IL1RN | rs17042888 | -0.3 | 0.924 | 0.268 | 5.69 | 0.038 | 0.380 |
| NT5E | rs6942065 | -5.9 | 0.028 | 0.323 | -2.65 | 0.34 | 0.345 |
| NT5E | rs10944128 | 1.9 | 0.361 | 0.278 | -0.46 | 0.822 | 0.336 |
| NT5E | rs2229524 | -0.9 | 0.774 | 0.269 | 0.05 | 0.988 | 0.335 |
| NT5E | rs2229523 | -0.1 | 0.961 | 0.268 | 0.27 | 0.907 | 0.335 |
SNPs meeting PRS inclusion threshold of p ≤ 0.2 in bold; positive β indicates that the minor allele is associated with poorer outcome; negative β indicates that the minor allele is associated with better outcome.
ACE, angiotensin converting enzyme; ADORA1, adenosine A1 receptor subtype gene; BA, behavioral adjustment; BDNF, brain-derived neurotrophic factor; EF, executive function; IL1RN, interleukin-1 receptor antagonist; NT5E, 5’-ectonucleotidase; PRS, polygenic risk scores; SNP, single nucleotide polymorphism; TBI, traumatic brain injury