Table 5.
Linear Regression Results Testing Inflammatory Response PRS × Injury Group Interaction
| Dependent variable | PRS | Parameter | Estimate | p | Adj R2 | Δ Adj R2 |
|---|---|---|---|---|---|---|
| EF | Unweighted | |||||
| Pre-morbid EF | 0.421 | 0 | ||||
| Continental ancestry | -38.455 | 0.002 | ||||
| uwPRS | 0.723 | 0.012 | ||||
| Injury group | -7.795 | 0 | 0.429 | |||
| uwPRS × injury group | -1.452 | .008 | 0.456 | 0.027 | ||
| Weighted | ||||||
| Pre-morbid EF | 0.423 | 0 | ||||
| Continental ancestry | -39.121 | 0.002 | ||||
| wPRS | 0.186 | 0.014 | ||||
| Injury group | -7.874 | 0 | 0.428 | |||
| wPRS × injury group | -0.406 | 0.004 | 0.460 | 0.032 | ||
| BA | Unweighted | |||||
| Pre-morbid BA | 0.527 | 0 | ||||
| Continental ancestry | -4.859 | 0.712 | ||||
| zSES | -2.049 | .040 | ||||
| uwPRS | 1.242 | .047 | ||||
| Injury group | -7.422 | 0 | 0.459 | |||
| uwPRS × injury group | -2.536 | .038 | 0.473 | 0.014 | ||
| Weighted | ||||||
| Pre-morbid BA | 0.525 | 0 | ||||
| Continental ancestry | -3.811 | 0.770 | ||||
| zSES | -1.998 | 0.044 | ||||
| wPRS | 0.393 | 0.026 | ||||
| Injury group | -7.400 | 0 | 0.463 | |||
| wPRS × injury group | -0.744 | 0.032 | 0.478 | 0.015 |
BA, behavioral adjustment; EF, executive functioning; injury group, traumatic brain injury versus orthopedic injury; PRS, polygenic risk score; uwPRS, unweighted polygenic risk score; wPRS, weighted polygenic risk score; zSES, socioeconomic status z score.