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. 2020 Jun 9;37(13):1491–1503. doi: 10.1089/neu.2019.6866

Table 6.

Linear Regression Results Testing Inflammatory Response PRS within the TBI Group

Dependent variable PRS Parameter Estimate p Adj R2 Δ Adj R2
EF Unweighted          
    Pre-morbid EF 0.438 0    
    Continental ancestry -30.530 0.081    
          0.291  
    uwPRS 1.466 <0.001 0.409 0.118
  Weighted          
    Premorbid EF 0.438 0    
    Continental ancestry -30.530 0.081    
          0.291  
    wPRS 0.406 <0.001 0.419 0.128
BA Unweighted          
    Pre-morbid BA 0.506 0    
    Continental ancestry 1.847 0.919    
    zSES -3.071 0.039    
          0.346  
    uwPRS 2.574 0.005 0.417 0.071
  Weighted          
    Pre-morbid BA 0.506 0    
    Continental ancestry 1.847 0.919    
    zSES -3.071 0.039    
          0.346  
    wPRS 0.775 0.003 0.427 0.081

BA, behavioral adjustment; EF, executive functioning; PRS, polygenic risk score; TBI, traumatic brain injury; uwPRS, unweighted polygenic risk score; wPRS, weighted polygenic risk score; zSES, socioeconomic status z score.