Table 7.
Linear Regression Results Testing Inflammatory Response PRS within the OI Group
| Dependent variable | PRS | Parameter | Estimate | p | Adj R2 |
|---|---|---|---|---|---|
| EF | Unweighted | ||||
| Pre-morbid EF | 0.449 | 0 | |||
| Continental ancestry | -28.657 | 0.093 | |||
| 0.265 | |||||
| uwPRS | -0.168 | 0.674 | 0.255 | ||
| Weighted | |||||
| Pre-morbid EF | 0.449 | 0 | |||
| Continental ancestry | -28.657 | 0.093 | |||
| 0.265 | |||||
| wPRS | -0.059 | 0.568 | 0.257 | ||
| BA | Unweighted | ||||
| Pre-morbid BA | 0.567 | 0 | |||
| Continental ancestry | -9.630 | 0.633 | |||
| zSES | -0.512 | 0.713 | |||
| 0.313 | |||||
| uwPRS | -0.255 | 0.768 | 0.302 | ||
| Weighted | |||||
| Pre-morbid BA | 0.567 | 0 | |||
| Continental ancestry | -9.630 | 0.633 | |||
| zSES | -0.512 | 0.713 | |||
| 0.313 | |||||
| wPRS | -0.015 | 0.950 | 0.301 |
BA, behavioral adjustment; EF, executive functioning; OI, orthopedic injury; PRS, polygenic risk score; uwPRS, unweighted polygenic risk score; wPRS, weighted polygenic risk score; zSES = socioeconomic status z score.