Fig 7. Creating the holdout datasets.

This shows an example of how a holdout dataset was created. Using the virus host interaction matrix for bacteria hosts at the phylum level and the viruses at family level, the holdout datasets were made by: (1) Removing a family of viruses, here Podoviridae, from the data. These holdout viruses are made up of infecting/non-infecting viruses and are then used as the test data. (2) The rest of the viruses that infect/don’t infect the labelled host. Here the phylum Firmicutes are used to form the training set. And, (3) The training viruses were then filtered to remove any viruses that have greater than 75% ANI to any of the holdout/test viruses.