Table 2. Constants, parameters, and default steady state values for variables.
Symbol | Value | Description |
---|---|---|
Constants | ||
F | 96485.33 C mol-1 | Faraday constant |
R | 8.31446 J K-1 mol-1 | Universal gas constant |
T | 310.15 K | Absolute temperature (= 37˚C) |
Parameters | ||
τriseAMPA | 0.2 ms | AMPA rise time constant [59] |
τdecayAMPA | 1.7 ms | AMPA decay time constant [59] |
τriseNMDA | 2.04 ms | NMDA rise time constant [62] |
τdecayNMDA | 75.2 ms | NMDA decay time constant [62] |
αGABA | 5 mM-1 ms-1 | GABAA receptor binding rate [63] |
βGABA | 0.18 ms-1 | GABAA receptor unbinding rate [63] |
PKCC2 | 0.001 mM-1 s-1 1.9297 x 10−5 mA mM-2 cm-2 |
Pump strength for potassium-chloride cotransporter 2 (KCC2) |
[K+]i | 140 mM | Internal potassium concentration |
[Na+]i | 10 mM | Internal sodium concentration |
[HCO3-]i | 12 mM | Internal bicarbonate concentration |
[Cl-]o | 135 mM | External chloride concentration |
[K+]o | 4.0 mM | External potassium concentration |
[Na+]o | 140 mM | External sodium concentration |
[HCO3-]o | 23 mM | External bicarbonate concentration |
Variables (default steady state values) | ||
ECl- | -92.42 mV | Reversal potential for chloride |
[Cl-]i | 4.25 mM | Internal chloride concentration |
EGABA | -77.41 mV | Reversal potential for GABAAR |
Vm | -71.35 mV | Membrane Voltage |