Table 1. Postulated mechanism of phenotypic lag for different antibiotics discussed in this work.

Antibiotic	Target	Mechanism of resistance	Postulated phenotypic lag model
rifampicin	RNA polymerase	target mutation (rpoB), recessive	dilution+polyploidy
fluoroquinolones	DNA topoisomerases	target mutation (gyrA, gyrB, parC), recessive	dilution+polyploidy
polymixins	lipo-poly-saccharide (LPS)	mutations in enzymes modifying the structure of LPS	dilution+polyploidy
beta-lactams	enzymes in cell wall synthesis	inactivation by beta-lactamase, dominant	accumulation
tetracycline	ribosomes	efflux upregulation, production of a protective protein	accumulation
many antibiotics	different targets	upregulation of efflux pumps, dominant	accumulation