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Schematic diagram depicting the protection mechanisms of TRAP1 in H9C2 cells under conditions of extracellular acidification. TRAP1 inhibits acid-induced MPTP opening and the expression or activation of apoptosis protein to protect mitochondrial function, which attenuates H9C2 cell injury and apoptosis under conditions of extracellular acidification. TRAP1, tumor necrosis factor receptor-associated protein 1.
