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. 2020 May 20;46(2):782–794. doi: 10.3892/ijmm.2020.4611

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Copyright: © Tian et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Changes in the current density carried by Na_v1.7 following administration of AOAA or U0126 in DRG neurons of SNI rats. (A) Representative traces showing the sodium current in DRG neurons stimulated using a step protocol from -100 to 20 mV in 10 mV increments with a pulse duration of 100 msec. Before: Traces before cells were perfused with PF-04856264. PF-04856264: Traces after incubation with PF-04856264 for 60 sec. Net current: Traces obtained by subtracting the traces of PF-04856264 from the traces of Before. Wash out: Traces after the extracellular fluid was washed for 4 min. (B) Current density-voltage curves of DRG neurons from each group. ^*P<0.05 vs. Sham group. ^#P<0.05 vs. SNI+Vehicle group. n=7 per group. DRG, dorsal root ganglion; SNI, spared nerve injury; AOAA, O-(carboxymethyl) hydroxylamine hemihydrochloride; Na_v1.7, voltage-gated sodium channel 1.7.