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Schematic diagram of the CBS/H2S-MEK/ERK signaling pathway-mediated regulation of Nav1.7 expression. p-ERK may regulate the expression of Nav1.7 via CREB in the nucleus. Nav1.7, voltage-gated sodium channel 1.7; ERK, extracellular signal-regulated kinase; MEK, mitogen-activated protein kinase kinase; p, phosphorylated; CBS, cysta-thionine β-synthetase; CREB, cAMP-response element binding protein; H2S, hydrogen sulfide.
