Skip to main content
. 2020 May 14;46(2):762–772. doi: 10.3892/ijmm.2020.4604

Figure 6.

Figure 6

IL-1β treatment decreased the expression of tight junctional proteins in RBECs (n=4). (A) Immunoreactive bands of ZO-1 (220 kDa), occludin (59 kDa), claudin-5 (23 kDa) and β-actin (42 kDa). (B) There was decreased tight junctional protein expression in the IL-1β group compared with the control group (ZO-1: **P<0.01; occludin: **P<0.01; and claudin-5: **P<0.01). The expression of tight junctional proteins was significantly upregulated following IL-1Ra treatment (ZO-1: **P<0.01; occludin: **P<0.01; and claudin-5: *P<0.05). RBECs, rat brain capillary endothelial cells; ZO-1, zonula occludens-1; IL-1β, interleukin-1β; IL‑1Ra, interleukin‑1 receptor antagonist; ns, non‑significant.