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. 2020 May 14;46(2):762–772. doi: 10.3892/ijmm.2020.4604

Figure 7.

Figure 7

Hypercapnia enhanced blood-brain barrier permeability in hypoxemic rats (n=4). (A) There was an interaction effect between hypoxia treatment and hypercapnia treatment (P<0.01). (B) Simple effects analyses revealed increased extravasation of EB in the hypoxemia group (**P<0.01), but not in the hypercapnia group (P>0.05) compared with the Sham group. The extravasation of EB was the most notable in the HH group compared with the hypoxemia group (**P<0.01) and the hypercapnia group (**P<0.01). The concentrations of O2 and CO2 in the air were 21 and 0.03%, respectively. EB, Evans blue; HH group, hypercapnia + hypoxemia; ns, non‑significant.