Table 4. Examples for Resistance-Breaking Compounds.
| resistance breaker | antibiotic | mechanism | ref |
|---|---|---|---|
| clavulanatea | amoxicilline | β-lactamase inhibitor | (165, 166) |
| avibactama | ceftazidime, ceftaroline, aztreonam | β-lactamase inhibitor | (221) |
| vaborbactama | Meropenem | β-lactamase inhibitor | (221) |
| tazobactama | ceftolozane | β-lactamase inhibitor | (221) |
| compound 1 | amikacin | inhibitor of aminoglycoside-modifying enzymes | (222) |
| PAβN | erythromycin, chloramphenicol | efflux pump inhibitor | (223) |
| verapamil | bedaquiline, ofloxacin | efflux pump inhibitor | (224, 225) |
| IMP-1700 | quinolones | sensitizer (SOS response) | (212, 217) |
| colistina | rifampin | permeabilizer | (226−228) |
| dispersin B | several possible | biofilm inhibitor | (229−231) |
| dehydrocrepenyc acid | several possible | inhibitor of horizontal gene transfer | (232) |
| streptazolin | several possible | immunomodulator | (233) |
a
Combination in clinical use.