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. 2020 Feb 26;142(12):5751–5759. doi: 10.1021/jacs.9b13700

Table 1. Optimization of the Reaction Conditionsa.

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a

Unless otherwise noted, the following reaction conditions were employed: 1a (0.1 mmol, 1.0 equiv), 2a (0.15 mmol, 1.5 equiv), Pd(OAc)2 (5 mol %), ETM1 (5 mol %), ETM2 (10 mol %), in 0.2 M THF, O2 (balloon, 1 atm) at room temperature (23 °C) for 24 h. Yields and conversions were determined by 1HNMR using anisole as internal standard.

b

H2O (0.5 equiv) was added to the reaction mixture.

c

H2O (1.0 equiv) was added to the reaction mixture.

d

H2O (2.0 equiv) was added to the reaction mixture.

e

The reaction was run with 10 mol % of Co(salophen)-HQ for 36 h.