Table 1.
Characteristics of participants by cystatin C tertile groups
| All Subjects | Cystatin C < 1.35 |
Cystatin C 1.35–1.81 |
Cystatin C 1.82+ |
P-value† | |
|---|---|---|---|---|---|
| Number of subjects | 193 | 63 | 65 | 65 | |
| Mean + SD Range |
Mean + SD Range |
Mean + SD Range |
Mean + SD Range |
||
| Age (years) at blood draw | 93.9 + 3.0 90 to 107 |
93.2 + 2.9 90 to 104 |
93.6 + 2.4 90 to 99 |
94.8 + 3.3 90 to 107 |
0.006 |
| Cystatin C | 1.62 + 0.53 0.74 to 3.02 |
1.07 + 0.17 0.74 to 1.34 |
1.54 + 0.12 1.35 to 1.81 |
2.25 + 0.34 1.82 to 3.02 |
<0.0001 |
| eGFR | 39.2 + 17.7 14 to 92 |
59.8 + 13.7 41 to 92 |
36.1 + 4.3 28 to 45 |
22.2 + 4.2 14 to 29 |
<0.0001 |
| Days to neuropsychological exam | 15 + 44 −102 to 202 |
12 + 42 −84 to 202 |
11 + 38 −102 to 132 |
21 + 50 −99 to 133 |
0.34 |
| No. (%) | No. (%) | No. (%) | No. (%) | ||
| Female | 118 (61%) | 38 (60%) | 41 (63%) | 39 (60%) | 0.95 |
| Education: college grad | 104 (54%) | 37 (59%) | 30 (46%) | 37 (57%) | 0.31 |
| Never smoked (missing=1) | 104 (54%) | 31 (50%) | 40 (62%) | 33 (51%) | 0.35 |
| Medical History | |||||
| High blood pressure | 119 (62%) | 34 (54%) | 40 (62%) | 45 (69%) | 0.22 |
| Diabetes | 24 (12%) | 8 (13%) | 6 (9%) | 10 (15%) | 0.56 |
| Coronary artery disease | 24 (12%) | 5 (8%) | 6 (9%) | 13 (20%) | 0.10 |
| Heart attack | 14 (7%) | 2 (3%) | 5 (8%) | 7 (11%) | 0.27 |
| Heart valve disease | 9 (5%) | 3 (5%) | 1 (2%) | 5 (8%) | 0.25 |
| Congestive heart failure * | 15 (8%) | 1 (2%) | 3 (5%) | 11 (17%) | 0.004 |
| Stroke | 19 (10%) | 4 (6%) | 7 (11%) | 8 (12%) | 0.56 |
| TIA | 35 (18%) | 8 (13%) | 14 (22%) | 13 (20%) | 0.38 |
| Any of above | 145 (75%) | 41 (65%) | 51 (78%) | 53 (82%) | 0.05 |
| Depression ** | 21 (11%) | 4 (6%) | 4 (6%) | 13 (20%) | 0.02 |
†
for difference among cystatin C tertile groups
*
Mean cystatin C in persons with vs without congestive heart failure: 2.14 + 0.56 vs 1.58 + 0.51 mg/L, p<0.0001
**
Mean cystatin C in persons with vs without depression : 1.81 + 0.48 vs 1.60 + 0.54 mg/L, p=0.09