Table 4.
MRI findings by cystatin C tertile groups
| All Subjects | Cystatin C < 1.35 |
Cystatin C 1.35–1.81 |
Cystatin C 1.82+ |
P-value† | |
|---|---|---|---|---|---|
| Cerebral Microbleeds (CMB) | No. (%) | No. (%) | No. (%) | No. (%) | |
| Number of subjects | 127 | 40 | 44 | 43 | |
| Any CMB | 29 (23%) | 7 (17%) | 9 (20%) | 13 (30%) | 0.36 |
| Infratentorial CMB | 9 (7%) | 0 (0%) | 3 (7%) | 6 (14%) | 0.04 |
| Deep CMB | 8 (6%) | 2 (5%) | 2 (5%) | 4 (9%) | 0.66 |
| Lobar CMB | 18 (14%) | 6 (15%) | 6 (14%) | 6 (14%) | 1.00 |
| Lobar CMB only | 15 (12%) | 5 (12%) | 5 (11%) | 5 (12%) | 1.00 |
| % of total brain volume | Mean + SD Range |
Mean + SD Range |
Mean + SD Range |
Mean + SD Range |
P-value† |
| Number of subjects | 124 | 40 | 43 | 41 | |
| Total cerebral spinal fluid | 28.7 + 1.93 25.1 to 34.4 |
28.1 + 1.70 25.1 to 31.7 |
28.9 + 2.09 25.4 to 34.4 |
29.1 + 1.87 25.5 to 33.3 |
0.05 |
| Total gray matter | 41.3 + 1.80 36.9 to 46.7 |
42.2 + 1.81 37.5 to 46.7 |
40.9 + 1.51 38.1 to 44.3 |
40.8 + 1.81 36.9 to 44.0 |
0.0007 |
| Total white matter | 28.9 + 2.10 24.0 to 34.4 |
28.8 + 2.01 25.0 to 32.5 |
29.0s + 2.27 24.0 to 34.4 |
29.0 + 2.03 24.7 to 33.4 |
0.88 |
| Total white matter hyperintensities (missing=14) | 1.21 + 0.98 0.0004 to 5.06 |
1.13 + 1.03 0.06 to 3.78 |
1.39 + 0.94 0.0004 to 3.23 |
1.11 + 0.97 0.087 to 5.06 |
0.39 |
†
for difference among cystatin C tertile groups