Table 4. SAR Exploration of 2,5-Dichloro Analogues.

^aMean of ≥3 independent experiments ± standard error. Efficacy (E_max) is relative to maximal response of propionate.

^bCalculated by ChemDraw Professional version 16.

^cKinetic solubility at 25 °C in phosphate buffered saline pH 7.4 (PBS_7.4).

^dNo response.