Table 6. In Vitro Stability and in Vivo Pharmacokinetic Properties of Selected Compounds in Mice.

					iv dosing (5 mg/kg)			po dosing (10 mg/kg)
	cAMP pEC50a	aq. sol. (μM)a	log D7.4a	MLM (%)b	t1/2 (min)	Vd (mL/kg)	CLtotal (mL/min/kg)	t1/2 (min)	tmax (min)	cmax (ng/mL)	AUCinf (ng.min/mL)	F (%)
1	6.28	190	2.05	52	62.2	759	8.45	89.7	15	7470	865 000	73
16	6.89	5	3.19	1	22.3	629	19.6	60.8	30	5740	423 000	88
35	5.92	199	2.64	23
47	6.60	1	3.39	2
51	6.72	1	2.59	12
57	6.84	33	4.25	1	11.4	1150	70.3	63.5	30	561	33 800	36
62	6.60	5	3.73	1
63	6.79	9	>4.3	41	37.8	1110	20.3	51.8	15	3800	325 000	66

^aMost data are replicated from Tables 1 and 3–5 (for SEM and E_max, see these tables).

^bRemaining after 40 min incubation with MLMs.