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(A) Substitution patterns of the most common NBTI linker fragments. These comprise a representative central unit (linker) and the optimal two-atom linkage. (B) 3D representation of an example aminopiperidine linker moiety (inset, gray, stick representation) and its key ionic interaction (red dots) between the protonated basic amine of the linker and Asp83 of GyrA (inset, green, stick representation; PDB code 2XCS),4 which is required for correct antibacterial activity.
