. 2020 Feb 6;63(11):5664–5674. doi: 10.1021/acs.jmedchem.9b01738

Table 1. Summary of Selected, Most Promising NBTIs for Their Enzyme Inhibition (IC₅₀) and Antibacterial Activities (MIC) against Gram-Negative and Gram-Positive Bacteria, Including Their Cardiotoxicities (hERG)^k.

IC₅₀ for enzyme supercoiling (gyrase) and relaxation (topo IV).

MIC of one strain.

MIC₉₀ of more strains.

S. aureus WCUH 29.

S. pneumoniae 1629.

H. influenzae H128.

S. pneumoniae TPS3.

S. aureus ATCC 29213.

ⁱ

E. coli ATCC 25922.

S. pneumoniae ATCC 49619.

MIC = minimum inhibitory concentration. NR = not reported.

Table 1. Summary of Selected, Most Promising NBTIs for Their Enzyme Inhibition (IC50) and Antibacterial Activities (MIC) against Gram-Negative and Gram-Positive Bacteria, Including Their Cardiotoxicities (hERG)k.