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. 2020 Jan 9;63(3):1361–1387. doi: 10.1021/acs.jmedchem.9b01886

Table 2. Kinetic Parameters for the Reversible and Irreversible Inhibition of the hMAOs by the Selected 4-Styrylpiperidine Inhibitors.

		reversible inhibition	irreversible inhibition
MAO	inhibitor	K_i (μM)	K_I (μM)	k_inact (min^–1)	k_inact/K_I (min^–1 μM^–1)
hMAO-A	69	0.23 ± 0.02	1.01 ± 0.76	1.25 ± 0.25	1.24
	clorgyline^a	0.040 ± 0.004^b	0.22 ± 0.08^b	0.12 ± 0.05^b	0.55^b
hMAO-B	1	1.92 ± 0.32	1.38 ± 0.29	0.66 ± 0.04	0.48
	84	1.25 ± 0.23	17.25 ± 4.38	2.03 ± 0.38	0.12
	97	1.36 ± 0.31	6.55 ± 1.62	1.04 ± 0.12	0.16
	l-deprenyl^a	0.97 ± 0.11	5.68 ± 0.78	2.56 ± 0.24	0.45

^a

Kinetic parameters were compared to clorgyline and l-deprenyl in the cases of hMAO-A and hMAO-B selective inhibitors, respectively.

^b

Data from Esteban et al. (2014).²⁵