. 2020 Jan 9;63(3):1361–1387. doi: 10.1021/acs.jmedchem.9b01886

Table 3. In Vitro and ex Vivo Mouse Brain Homogenate Residual Activities of 69 and 100 at 60 mg/kg ip on MAO-A and MAO-B According to Substrate^a.

	residual activity (%)
	MAO-A substrate		MAO-A/B substrate		MAO-B substrate
	5-HT (0.25 mM)		p-tyramine (0.5 mM)		benzylamine (0.5 mM)
compd	in vitro^b	ex vivo^c	in vitro^b	ex vivo^c	in vitro^b	ex vivo^c
69	–1.3 ± 0.1	1.6 ± 0.02	31.3 ± 0.2	14.2 ± 0.2	nd	nd
100	nd	nd	59.4 ± 0.2	77.2 ± 0.2	–7.7 ± 0.2	24.3 ± 0.5

Data are mean values ± SD (n = 1, in triplicate). nd, not determined.

In vitro: 50 μM compounds (final concentrations) versus 0.9% saline with mouse brain homogenate from nontreated mice.

Ex vivo: brain homogenates from mice treated (n = 3, per group) with 60 mg/kg ip compounds or 0.9% saline 30 min before brain homogenate preparation.

Table 3. In Vitro and ex Vivo Mouse Brain Homogenate Residual Activities of 69 and 100 at 60 mg/kg ip on MAO-A and MAO-B According to Substratea.

Table 3. In Vitro and ex Vivo Mouse Brain Homogenate Residual Activities of 69 and 100 at 60 mg/kg ip on MAO-A and MAO-B According to Substrate^a.